Harness the Power of Triple Helix

Harness the Power of Triple Helix

Targeting collagen whose unique triple helical structure is damaged during illness and injury
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Collagen Hybridizing Peptide (CHP)

Collagen Hybridizing Peptide (CHP)

A mini collagen strand that specifically binds the unfolded collagen chains
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Rigorous Science

Rigorous Science

A technology based on numerous studies in high-profile publications
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Innovative Technology

Innovative Technology

Advancing our compounds towards a new class of diagnostic and therapeutic agents for unmet medical needs
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Collagen has a unique triple helical structure that is unfolded in tissues during diseases, development, mechanical injury, and decellularization. 3Helix commercializes labeled collagen hybridizing peptide (CHP) that specifically binds to such unfolded collagen chains, enabling unlimited laboratory applications in pathology, biomechanics, cell biology, regenerative medicine, and more.
CHP detects tissue damage and remodeling in a large variety of diseases through binding to degraded collagen
Collagen Identification
CHP visualizes collagen bands of all types in SDS-PAGE with high specificity
Tissue Decellularization
CHP enables assessment of collagen denaturation in decellularized extracellular matrix
Mechanical Damage
CHP can measure and localize mechanical injury to collagenous tissue at the molecular level
Cell Invasion
CHP visualizes pericellular collagen turnover caused by proteolytic migration of cells within 3D culture
In vivo Imaging
Under development

Our Users

CHP is trusted by investigators from

Try CHP in your study

  A unique tool to investigate collagen degradation or denaturation

  A non-antibody approach with no species restrictions

  High affinity and unparalleled specificity

  Applicable to nearly every tissue type

  Applicable to collagens of all types from all species


Targeting collagen strands by photo-triggered triple-helix hybridization. Proc. Natl. Acad. Sci. U.S.A. (2012) More info

Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides. Nat. Commun. (2017) More info

In situ imaging of tissue remodeling with collagen hybridizing peptides. ACS Nano (2017) More info

Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging. Biomaterials (2018) More info

Molecular assessment of collagen denaturation in decellularized tissues using a collagen hybridizing peptide. Acta Biomater. (2017) More info

Direct detection of collagenous proteins by fluorescently labeled collagen mimetic peptides. Bioconjug. Chem. (2013) More info

Targeting and mimicking collagens via triple helical peptide assembly. Curr. Opin. Chem. Biol. (2013) More info

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3Helix has developed a series of proprietary collagen hybridizing peptides that directly target the damaged collagen molecule. Collagen is the major component of nearly every human tissue, with an essential role in supporting cell growth and tissue formation. Damage to collagen is a strong indication of connective tissue injury, as well as a variety of diseases involving inflammation and abnormal tissue remodeling, such as cancer, myocardial infarction, arthritis, osteoporosis, and fibrosis. However, targeting damaged collagen is difficult with conventional technologies. In addition to providing CHP as a research tool for laboratory use in academia and industry, 3Helix is advancing its compounds to enable new pathways to achieving diagnostic and therapeutic objectives.

3Helix is based in Salt Lake City, Utah. It was founded by Drs. Yang Li and Michael Yu based on the technology that they invented at the Johns Hopkins University.

Founder Prof. Michael Yu describes examples of the vast potential medical applications of CHP, which was previously termed collagen mimetic peptide. (No access to Youtube? Watch the video here.)

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