Collagen Hybridizing Peptides (CHPs)

Short, single-stranded collagen-like peptides that bind to damaged and denatured collagen; useful for monitoring disease progression, injury resolution, and collagen content

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Wide Variety of Applications

CHPs are useful in histopathology, identifying mechanical damage, tissue decellularization, collagen identification, and cell invasion studies

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Harness the Power of Triple Helix

CHPs have a proven track record for identifying damaged collagen in many high-profile publications

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Innovative Technology

Empowering collagen targeting for diagnosis and treatment of human conditions

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Applications

Collagen has a unique triple helical structure that is unfolded in tissues during diseases, development, mechanical injury, and decellularization. 3Helix commercializes labeled collagen hybridizing peptide (CHP) that specifically binds to such unfolded collagen chains, enabling unlimited laboratory applications in pathology, biomechanics, cell biology, regenerative medicine, and more.

Histopathology

CHP detects tissue damage and remodeling in a large variety of diseases through binding to degraded collagen

Collagen Identification

CHP visualizes collagen bands of all types in SDS-PAGE with high specificity

Tissue Decellularization

CHP enables assessment of collagen denaturation in decellularized extracellular matrix

Mechanical Damage

CHP can measure and localize mechanical injury to collagenous tissue at the molecular level

Cell Invasion

CHP visualizes pericellular collagen turnover caused by proteolytic migration of cells within 3D culture

In vivo Imaging

New CHP sequence with a near-infrared fluorophore (NIRF) conjugation enables imaging collagen turnover in vivo

Publications

Targeting collagen strands by photo-triggered triple-helix hybridization. Proc. Natl. Acad. Sci. U.S.A. (2012) More info

Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides. Nat. Commun. (2017) More info

In situ imaging of tissue remodeling with collagen hybridizing peptides. ACS Nano (2017) More info

Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging. Biomaterials (2018) More info

Molecular assessment of collagen denaturation in decellularized tissues using a collagen hybridizing peptide. Acta Biomater. (2017) More info

Direct detection of collagenous proteins by fluorescently labeled collagen mimetic peptides. Bioconjug. Chem. (2013) More info

Targeting and mimicking collagens via triple helical peptide assembly. Curr. Opin. Chem. Biol. (2013) More info

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