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Osteoarthritis (OA), a debilitating degenerative joint disorder, is characterized by progressive cartilage degradation. Current treatments for osteoarthritis focus on managing symptoms like pain and stiffness through medications (oral and topical), physical therapy, exercise, supportive devices, and sometimes joint injections or surgery in severe cases, with currently no cure to reverse cartilage damage. In the...

Collagen Hybridizing Peptides track mast cell-driven collagen remodeling & degradation in neovascular Age-related Macular Degeneration (nAMD) research. Explore the study's key insights and learn about how you can target damaged collagen for insights in your research!

Validate collagen integrity in your biomaterials with 3helix CHPs. Discover how Collagen Hybridizing Peptides (CHPs, 3Helix Inc.) ensure reliable data in tissue engineering and bone remodeling research. 

Peripheral Nerve Injuries (PNIs) represent a significant clinical challenge, frequently resulting in disability and chronic pain, particularly in younger patients. Recovery following PNI is oftentimes unpredictable and the decision to pursue surgical intervention is complicated by a limited ability to accurately assess the severity and extent of tissue damage. The current PNI classification system,...

     Extracellular matrix (ECM) degradation, particularly damage to structural collagen, is a hallmark of numerous pathologies, including Intervertebral Disc (IVD) degeneration. Assessing the structural integrity of collagen in situ is critical for understanding disease mechanisms and evaluating the efficacy of potential interventions. Collagen Hybridizing Peptides (3Helix, Inc.) offer a unique tool for this...

Collagen is skin's foundation, but how it's truly built has been hidden – until now. Discover how see-through axolotls are providing an unprecedented window into this process, revealing secrets that could reshape skin science.

  Ehlers-Danlos syndrome (EDS) is a cluster of connective tissue disorders with a range of manifestations across organ systems. Periodontal EDS (pEDS) is a form of EDS characterized by weakening tissue around the teeth, leading to fragile gums, gingival recession, and tooth loss. pEDS has been linked to heterozygous missense mutations in the genes...

  Bone is a remarkable material, strong enough to withstand impressive forces without fracturing. Despite decades of research, however, our understanding of the molecular mechanisms underlying bone’s fracture resistance has remained incomplete. It has long been hypothesized that collagen degradation occurs following bone fracture. Until recently, this hypothesis lacked empirical evidence due to a...