Collagen Hybridizing Peptides (CHPs) Can Monitor the Fibrotic Progression and Response to Treatment of Idiopathic Pulmonary Fibrosis

Introduction

Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease where healthy tissue is replaced by fibrotic scar tissue, disrupting lung function and causing severe oxygen deficits. IPF is characterized by its rapid progression, and similar clinical presentation to other Interstitial Lung Diseases (ILDs), complicating its diagnosis, monitoring, and treatment with current methods. Collagen Hybridizing Peptides (CHPs), by selectively binding to degraded collagen, offer researchers the ability to actively monitor fibrotic changes in vivo. These capabilities can facilitate better understanding of IPF to enable earlier diagnoses and investigate novel therapeutics.

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