Subretinal Fibrosis Identified and Confirmed as Collagen for the First Time

Introduction

Neovascular Age-related Macular Degeneration (nAMD) is a progressive fibrotic condition characterized by abnormal vasculature growth under the retina, leakage from which triggers a fibrotic immune response leading to irreversible damage and blindness. Early detection and accurate diagnosis of nAMD are citical for effective management, however current methods often fail to detect early stage disease and assess the full extent of fibrosis. Collagen Hybridizing Peptides have been shown to bind to fibrotic scarring in nAMD for the continuous monitoring of disease progression and response to treatment.

Citations

Linder, Markus, et al. "In vivo monitoring of active subretinal fibrosis in mice using collagen hybridizing peptides." Lab Animal (2024): 1-9.

Corano Scheri, Katia, et al. "Limited Hyperoxia-Induced Proliferative Retinopathy (LHIPR) as a Model of Retinal Fibrosis, Angiogenesis, and Inflammation." Cells 12.20 (2023): 2468.