Collagen Hybridizing Peptides can directly monitor active fibrosis dynamics in vivo

Subretinal fibrosis is a critical driver of irreversible vision loss in neovascular Age-related Macular Degeneration (nAMD). Characterizing the dynamics of this fibrotic process, particularly distinguishing active collagen remodeling from scar tissue in vivo, is essential for developing and evaluating effective treatments. But this remains a major challenge. Current ophthalmic imaging lacks specific molecular probes to directly visualize active fibrosis in the back of the eye.

CHPs selectively target and visualize collagen damage resulting from fibrosis, allowing researchers to:

  • Directly image and map active subretinal fibrosis in vivo within relevant preclinical models (Laser-CNV, JR5558) correlating CHP signal intensity with histological fibrosis markers and disease activity.
  • Monitor disease activity dynamically by differentiating between active, progressing fibrosis (indicated by higher CHP binding) and stable or regressing scars (lower CHP binding) non-invasively over time.
  • Quantify changes in collagen remodeling in response to therapeutic interventions, providing a direct molecular readout to assess the efficacy of antifibrotic treatments targeting Subretinal Fibrosis

CHPs: Advancing nAMD Research with Direct In Vivo Fibrosis Monitoring

Explore how Collagen Hybridizing Peptides can provide unprecedented insights into active subretinal fibrosis within your nAMD research models. Dive deeper into the methodology and findings presented in our paper with Roche Ophthalmology.

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A versatile and sensitive solution for fibrosis characterization

CHPs enable the precise measurement of inflammation and tissue damage in a number of conditions.

Intensity of BCHP staining correlates with disease activity in MASH mouse model

At 3Helix, our CHP products provide:

  • Compatibility with most dyes, imaging probes, and automated staining platforms
  • Utility in histology, in vivo studies, and 3D cell cultures
  • Flexibility for use across any animal model and in human studies
  • The only product on the market to stain damaged collagen with applications available in total collagen staining

Our CHP products are conjugated with a variety of detection motifs for brightfield and fluorescence detection, and they can be customized to meet your unique needs. Visit our products page to learn more.

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