Unlock the secrets of PDAC's fibrotic stroma with Collagen Hybridizing Peptides

Accurately mapping collagen distribution and changes within the TME is crucial for effective interrogation of PDAC tumors. PDAC is notoriously challenging to treat due to its dense, collagen-rich desmoplastic stroma, which creates a barrier to immune cell infiltration, hindering drug delivery and promoting tumor progression.

Collagen Hybridizing Peptides (CHPs) selectively target and visualize denatured collagen to:

  • Precisely map collagen distribution and degradation within the PDAC microenvironment, revealing critical insights into tumor desmoplasia and invasion.
  • Quantify collagen changes in response to therapeutic interventions, providing a powerful tool for optimizing treatment combinations for PDAC.
  • Visualize the spatial relationships between collagen and other key TME components such as CAFs and immune cells to understand their complex interactions.

CHPs: Revolutionizing PDAC Research Through Targeted Collagen Analysis

Explore the potential of CHPs to overcome the challenges of PDAC research. Download our application note to discover how CHPs can transform your understanding of the PDAC tumor microenvironment.

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A versatile and sensitive solution for fibrosis characterization

CHPs enable the precise measurement of inflammation and tissue damage in a number of conditions.

Intensity of BCHP staining correlates with disease activity in MASH mouse model

At 3Helix, our CHP products provide:

  • Compatibility with most dyes, imaging probes, and automated staining platforms
  • Utility in histology, in vivo studies, and 3D cell cultures
  • Flexibility for use across any animal model and in human studies
  • The only product on the market to stain damaged collagen with applications available in total collagen staining

Our CHP products are conjugated with a variety of detection motifs for brightfield and fluorescence detection, and they can be customized to meet your unique needs. Visit our products page to learn more.

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