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Ligament injuries, particularly those affecting the Anterior Cruciate Ligament (ACL) or Medial Collateral Ligament (MCL), present a significant orthopedic challenge due to the tissue's poor vascularization and limited regenerative capacity. Decellularized extracellular matrix (dECM) scaffolds have emerged as a promising solution, offering a natural framework that minimizes immune rejection while theoretically preserving the native...

     Histological staining of mouse tibia-talus joints showing healthier articular cartilage due to iFab-CHP treatment compared PBS placebo.      Rheumatoid arthritis (RA) is a chronic autoimmune disease which leads to the breakdown of the cartilage in the synovial joints. Current treatment strategies with tumor necrosis factor-alpha (TNFa)  targeting neutralizing antibodies effectively reduce...

Biliary Atresia (BA) is a severe liver disease in infants, often leading to cirrhosis and death. Collagen Hybridizing Peptides (CHP) offer diagnostic and prognostic insights, aiding treatment decisions and organ transplant allocation.

Explore more about the impact of obesity-related pre-diabetic hyperglycemia on bone healing using the DIO mouse model. CHPs help reveal that deficits in collagen microstructure leads to impaired fracture healing in obese subjects.

In a recently accepted article published in Bioconjugate Chemistry, researchers from the University of Utah used CHPs in an antibody-conjugate to address Rheumatoid Arthritis(RA). In this paper, the authors used the Fab region from infliximab (an anti-TNFα therapy known as Remicade®) and conjugated this with CHPs. Figure Caption.  A) Biodistribution of IR680 labeled bFab-(NIRF)CHP...

Another great paper using CHPs! A recent article published in Wound Repair and Regeneration evaluated how the level of collagen denaturation within burned tissues influences the effectiveness of enzymatic debridement (removal of damaged tissue). They showed that low-temperature burns (<65 °C) had inadequate debridement, while high-temperature burns (>65 °C) had very effective debridement. By...

Learn more about how by utilizing CHPs, researchers studied post-IR pig heart damage. They found initial function decline, stable conditions later, and identified scar formation, corroborating Masson's Trichrome staining. No cardiomyocyte renewal observed.

Discover how Jeff Weiss's team at the University of Utah innovatively use Collagen Hybridizing Peptides to unveil tendon micro-damage mechanisms, shedding light on tendon fatigue and the crucial role that collagen triple-helix unfolding has in the human body.