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Liver fibrosis, a significant pathological consequence of chronic liver disease and damage, is characterized by the excessive accumulation of extracellular matrix (ECM) proteins. This build up of non-functional scar tissue progressively replaces healthy tissue in the liver, leading to conditions such as cirrhosis, liver failure, and heightened risk of liver cancer. With a high...

The complex interplay between the tumor microenvironment (TME) and cancer progression is a critical area of research, particularly in aggressive childhood cancers like neuroblastoma (NB). A recent study, “Unraveling the Role of Denatured Collagen in Neuroblastoma via Collagen Hybridizing Peptides,” published in July 2023, has shed light on the impact of thermal ablation on...

Osteoarthritis (OA), a debilitating degenerative joint disorder, is characterized by progressive cartilage degradation. Current treatments for osteoarthritis focus on managing symptoms like pain and stiffness through medications (oral and topical), physical therapy, exercise, supportive devices, and sometimes joint injections or surgery in severe cases, with currently no cure to reverse cartilage damage. In the...

Collagen Hybridizing Peptides track mast cell-driven collagen remodeling & degradation in neovascular Age-related Macular Degeneration (nAMD) research. Explore the study's key insights and learn about how you can target damaged collagen for insights in your research!

Validate collagen integrity in your biomaterials with 3helix CHPs. Discover how Collagen Hybridizing Peptides (CHPs, 3Helix Inc.) ensure reliable data in tissue engineering and bone remodeling research. 

Collagen is skin's foundation, but how it's truly built has been hidden – until now. Discover how see-through axolotls are providing an unprecedented window into this process, revealing secrets that could reshape skin science.

  Ehlers-Danlos syndrome (EDS) is a cluster of connective tissue disorders with a range of manifestations across organ systems. Periodontal EDS (pEDS) is a form of EDS characterized by weakening tissue around the teeth, leading to fragile gums, gingival recession, and tooth loss. pEDS has been linked to heterozygous missense mutations in the genes...

  Bone is a remarkable material, strong enough to withstand impressive forces without fracturing. Despite decades of research, however, our understanding of the molecular mechanisms underlying bone’s fracture resistance has remained incomplete. It has long been hypothesized that collagen degradation occurs following bone fracture. Until recently, this hypothesis lacked empirical evidence due to a...