Beyond Fibroblasts: CHPs provide Key Evidence for Keratinocyte-Driven Skin Development
Collagen is skin's foundation, but how it's truly built has been hidden – until now. Discover how see-through axolotls are providing an unprecedented window into this process, revealing secrets that could reshape skin science.
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Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease
Chronic kidney disease (CKD) progressively impairs kidney function, affecting millions. Beyond kidney-related complications, patients often experience muscle weakness and reduced mobility, begging the question: does muscle fibrosis contribute to those limitations? Figure 1 demonstrates a significant increase in collagen deposition within the vastus lateralis muscle of CKD patients. Histochemical analysis using picro-sirius red...
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Advancing Intervertebral Disc Degeneration Assessment with Collagen Hybridizing peptides: A Fast, Accurate Approach for Research and Clinical Applications
Intervertebral disc (IVD) degeneration is a significant contributor to lower back pain, a leading cause of disability in individuals over 45. IVD is marked by the degradation of collagen and the extracellular matrix, which triggers inflammatory responses, recruits macrophages, and accelerates degeneration. Monitoring the progression of IVD degeneration and assessing the effectiveness...
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