News

Tissue fibrosis, pathologically characterized by the excessive and dysfunctional deposition of extracellular matrix (ECM) components, notably collagen, remains a significant challenge in chronic disease management. Fibrosis accounts for nearly half of all mortality in the United States. Effective therapeutic strategies must engage a dual mechanism, simultaneously arresting neo-collagenesis and actively degrading existing, pathological collagen...

Abdominal Aortic Aneurysm (AAA) is a life-threatening condition characterized by the extensive remodeling and breakdown of the extracellular matrix (ECM). Understanding the factors governing aortic instability - particularly the micro/nanoscale changes - is paramount for improving AAA management. A new publication, "Nano-mechanical Mapping of Human and Porcine Abdominal Aortic Aneurysm" uses advanced imaging techniques...

The complex interplay between the tumor microenvironment (TME) and cancer progression is a critical area of research, particularly in aggressive childhood cancers like neuroblastoma (NB). A recent study, “Unraveling the Role of Denatured Collagen in Neuroblastoma via Collagen Hybridizing Peptides,” published in July 2023, has shed light on the impact of thermal ablation on...

Collagen is skin's foundation, but how it's truly built has been hidden – until now. Discover how see-through axolotls are providing an unprecedented window into this process, revealing secrets that could reshape skin science.

Staining of collagen in multiple organs with Biotin-conjugated Collagen Hybridizing Peptides (B-CHPs). The black and white panels are an extraction of the fluorescent peptide signal, used for quantification of collagen damage.        The universal process of aging involves the dysregulation of a wide spectrum of biological mechanisms. Using mouse models, DeLano et....