Visualizing Mast Cell-Driven Collagen Damage in nAMD Progression
Collagen Hybridizing Peptides track mast cell-driven collagen remodeling & degradation in neovascular Age-related Macular Degeneration (nAMD) research. Explore the study's key insights and learn about how you can target damaged collagen for insights in your research!
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Collagen Hybridizing Peptides Validate a Novel Bone Organoid Model
Validate collagen integrity in your biomaterials with 3helix CHPs. Discover how Collagen Hybridizing Peptides (CHPs, 3Helix Inc.) ensure reliable data in tissue engineering and bone remodeling research.
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Beyond Fibroblasts: CHPs provide Key Evidence for Keratinocyte-Driven Skin Development
Collagen is skin's foundation, but how it's truly built has been hidden – until now. Discover how see-through axolotls are providing an unprecedented window into this process, revealing secrets that could reshape skin science.
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First Empirical Evidence of Collagen Damage during Bone Fracture
Bone is a remarkable material, strong enough to withstand impressive forces without fracturing. Despite decades of research, however, our understanding of the molecular mechanisms underlying bone’s fracture resistance has remained incomplete. It has long been hypothesized that collagen degradation occurs following bone fracture. Until recently, this hypothesis lacked empirical evidence due to a...
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Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease
Chronic kidney disease (CKD) progressively impairs kidney function, affecting millions. Beyond kidney-related complications, patients often experience muscle weakness and reduced mobility, begging the question: does muscle fibrosis contribute to those limitations? Figure 1 demonstrates a significant increase in collagen deposition within the vastus lateralis muscle of CKD patients. Histochemical analysis using picro-sirius red...
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Detecting Early Arterial Damage in Atherosclerosis: How Collagen Hybridizing Peptides Overcome Diagnostic Challenges
Atherosclerosis, characterized by the buildup of plaque inside human arteries, is one of the leading causes of cardiovascular diseases. The disease is brought on by a complex interplay between lipids, inflammatory cells, and the ECM. Arterial blood flow is restricted as plaques form, which can rupture to cause blockage. Arterial blockage, or occlusion, is...
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CHPs’ can Help Predict Liver Survival in Biliary Atresia
Biliary Atresia (BA) is a severe liver disease in infants, often leading to cirrhosis and death. Collagen Hybridizing Peptides (CHP) offer diagnostic and prognostic insights, aiding treatment decisions and organ transplant allocation.
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Delayed Fracture Healing in Obesity-associated Type 2 Diabetic Mouse Model
Explore more about the impact of obesity-related pre-diabetic hyperglycemia on bone healing using the DIO mouse model. CHPs help reveal that deficits in collagen microstructure leads to impaired fracture healing in obese subjects.
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