News

Targeted Drug Delivery in Rheumatoid Arthritis: Leveraging Collagen Hybridizing Peptides for Enhanced Therapeutic Efficacy

Anthony Kolton 0 Comments

     Histological staining of mouse tibia-talus joints showing healthier articular cartilage due to iFab-CHP treatment compared PBS placebo.      Rheumatoid arthritis (RA) is a chronic autoimmune disease which leads to the breakdown of the cartilage in the synovial joints. Current treatment strategies with tumor necrosis factor-alpha (TNFa)  targeting neutralizing antibodies effectively reduce...
View Details

Localization of Therapeutic Fab-CHP Conjugates to Sites of Denatured Collagen for the Treatment of Rheumatoid Arthritis

Anthony Kolton 0 Comments

In a recently accepted article published in Bioconjugate Chemistry, researchers from the University of Utah used CHPs in an antibody-conjugate to address Rheumatoid Arthritis(RA). In this paper, the authors used the Fab region from infliximab (an anti-TNFα therapy known as Remicade®) and conjugated this with CHPs. Figure Caption.  A) Biodistribution of IR680 labeled bFab-(NIRF)CHP...
View Details