Uncovering Fibrosis: Superior Sensitivity of CHPs in Targeting IPF
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Discover how collagen hybridizing peptides (CHPs) outperform Masson's trichrome in detecting collagen in idiopathic pulmonary fibrosis (IPF) tissues.
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Effective enzymatic debridement of burn wounds depends on the denaturation status of collagen
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Another great paper using CHPs! A recent article published in Wound Repair and Regeneration evaluated how the level of collagen denaturation within burned tissues influences the effectiveness of enzymatic debridement (removal of damaged tissue). They showed that low-temperature burns (<65 °C) had inadequate debridement, while high-temperature burns (>65 °C) had very effective debridement. By...
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Collagen denaturation is initiated upon tissue yield in both positional and energy-storing tendons
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A great new article from a collaboration between Dr. Jeff Weiss's lab and our founder, Dr. Michael Yu's lab at the University of Utah. The new Acta Biomaterialia paper explores at what point collagen denaturation occurs in tendons under mechanical strain and how tendon type influences the mechanism of failure. Researchers evaluated functionally distinct...
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