Collagen Hybridizing Peptides (CHPs) Elucidate Ursolic Acid's Efficacy in Collagen Homeostasis
Tissue fibrosis, pathologically characterized by the excessive and dysfunctional deposition of extracellular matrix (ECM) components, notably collagen, remains a significant challenge in chronic disease management. Fibrosis accounts for nearly half of all mortality in the United States. Effective therapeutic strategies must engage a dual mechanism, simultaneously arresting neo-collagenesis and actively degrading existing, pathological collagen...
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Collagen denaturation is initiated upon tissue yield in both positional and energy-storing tendons
A great new article from a collaboration between Dr. Jeff Weiss's lab and our founder, Dr. Michael Yu's lab at the University of Utah. The new Acta Biomaterialia paper explores at what point collagen denaturation occurs in tendons under mechanical strain and how tendon type influences the mechanism of failure. Researchers evaluated functionally distinct...
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