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Hundreds of millions of people suffer from chronic back pain, often stemming from Degenerative Disc Disease (DDD). MRI imaging can visualize the structural decay of spinal discs, but what if DDD pathogenesis starts long before gross morphological degeneration is identified? For years, researchers have hypothesized that the real issues begin on the molecular level...

  Cardiovascular biology has seen significant advances in recent times, yet heart disease remains the leading cause of morbidity & mortality worldwide. A critical challenge following an acute Myocardial Infarction (MI, heart attack) is the irreversible loss of millions of cardiac muscle cells (Cardiomyocytes, CM). These lost cells are replaced by fibrotic scar tissue....

Staining of collagen in multiple organs with Biotin-conjugated Collagen Hybridizing Peptides (B-CHPs). The black and white panels are an extraction of the fluorescent peptide signal, used for quantification of collagen damage.        The universal process of aging involves the dysregulation of a wide spectrum of biological mechanisms. Using mouse models, DeLano et....