Collagen Hybridizing Peptides (CHPs) Elucidate Ursolic Acid's Efficacy in Collagen Homeostasis
Tissue fibrosis, pathologically characterized by the excessive and dysfunctional deposition of extracellular matrix (ECM) components, notably collagen, remains a significant challenge in chronic disease management. Fibrosis accounts for nearly half of all mortality in the United States. Effective therapeutic strategies must engage a dual mechanism, simultaneously arresting neo-collagenesis and actively degrading existing, pathological collagen...
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CHPs Contribute to Abdominal Aortic Anurrysm (AAA) Research)
Abdominal Aortic Aneurysm (AAA) is a life-threatening condition characterized by the extensive remodeling and breakdown of the extracellular matrix (ECM). Understanding the factors governing aortic instability - particularly the micro/nanoscale changes - is paramount for improving AAA management. A new publication, "Nano-mechanical Mapping of Human and Porcine Abdominal Aortic Aneurysm" uses advanced imaging techniques...
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Collagen Hybridizing Peptides (CHPs): Unraveling the role of Denatured Collagen in Neuroblastoma.
The complex interplay between the tumor microenvironment (TME) and cancer progression is a critical area of research, particularly in aggressive childhood cancers like neuroblastoma (NB). A recent study, “Unraveling the Role of Denatured Collagen in Neuroblastoma via Collagen Hybridizing Peptides,” published in July 2023, has shed light on the impact of thermal ablation on...
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