Decellularization Induces Hierarchical Disorganization in Ligament Scaffolds
Ligament injuries, particularly those affecting the Anterior Cruciate Ligament (ACL) or Medial Collateral Ligament (MCL), present a significant orthopedic challenge due to the tissue's poor vascularization and limited regenerative capacity. Decellularized extracellular matrix (dECM) scaffolds have emerged as a promising solution, offering a natural framework that minimizes immune rejection while theoretically preserving the native...
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How Collagen Hybridizing Peptides Reveal Hidden Molecular Damage Behind Back Pain
Hundreds of millions of people suffer from chronic back pain, often stemming from Degenerative Disc Disease (DDD). MRI imaging can visualize the structural decay of spinal discs, but what if DDD pathogenesis starts long before gross morphological degeneration is identified? For years, researchers have hypothesized that the real issues begin on the molecular level...
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