Interesting work from Dr. You Han Bae's lab at the University of Utah used F-CHPs aid in evaluating tissue perfusion and identifying barriers to transport in uterine fibroids. Fibroids are growths of dense connective tissue that lack vasculature for the transport of drugs to the area. They show that there is a negative relationship between collagen density and methylene blue distribution (used as a model molecule for tissue perfusion). They noted limit...
Are you interested in evaluating the mechanical damage of tissues or evaluating how collagen damage influences mechanical properties?? Well, then this paper is for you! A new article published in The Journal of the Mechanical Behavior of Biomedical Materials shows that CHPs can help give quantitative information regarding the damage to collagen fibers at a molecular level. The authors explain how this molecular-level damage influences the mechanical pr...
New work from the Niklas Bergh and Per Fogelstrand labs (University of Gothenburg and Sahlgrenska University Hospital) evaluated how decellularized blood vessels from tissue engineering can be a practical alternative to synthetic or autologous grafts that are commonly used in vascular surgery. They utilized CHPs to systematically compare collagen damage caused by decellularization of 5 different protocols using the following detergents: sodium dodecyl ...
