Uterine perfusion model for analyzing barriers to transport in fibroids

Uterine perfusion model for analyzing barriers to transport in fibroids
Interesting work from Dr. You Han Bae's lab at the University of Utah used F-CHPs aid in evaluating tissue perfusion and identifying barriers to transport in uterine fibroids. Fibroids are growths of dense connective tissue that lack vasculature for the transport of drugs to the area. They show that there is a negative relationship between collagen density and methylene blue distribution (used as a model molecule for tissue perfusion). They noted limit...

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.
Another exciting article that was published by the Watt Lab (King's College) in PLoS One utilized CHP technology to examine differences in dermal development in mice caused by lysyl oxidase-like 2 (LOXL2) which contributes to the remodelling of the ECM. They used the new CHP to assess and quantify the difference in collagen fiber structure between a LOXL2 knock-out, knock-in and control mice from postnatal day 2 up to day 120. Abstract: Lysyl oxidase-l...
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