Interesting new work published in The American Journal of Physiology- Cell Physiology evaluated the ability of muscle-derived pericyte to contribute to skeletal muscle remodeling in response to training. The researchers used electric stimulation to contract muscles and monitor the response of pericyte cells. They found that the CD146+ Lin- pericyte cells were the most sensitive to contraction and they contribute to upregulating ECM remodeling and angio...
A recent article published in the International Journal of Molecular Sciences utilized CHPs to verify the health of collagen in their MSC-ECM complexes. The authors developed a clumped-MSC/ECM (C-MSC) complex under serum-free conditions that allows bone regeneration upon implantation without the use of an artificial scaffold. They grew the C-MSC and compared a cellularized vs decellularized C-MSCs for their ability to promote osteogenesis after implanta...
EXTRA! EXTRA! Read all about it! New research from Jeffery Molkentin's Lab recently utilized B-CHP to evaluate the mechanical and functional changes in cardiac tissue following an ischemia/reperfusion injury and evaluated the difference in the response following stem cell therapy. In Panel A, the clearly show that there is an increase in ECM remodeling at the infarct border zone compared to an area far away from the infarct. In Panel B, they show that ...
