Localization of Therapeutic Fab-CHP Conjugates to Sites of Denatured Collagen for the Treatment of Rheumatoid Arthritis

Localization of Therapeutic Fab-CHP Conjugates to Sites of Denatured Collagen for the Treatment of Rheumatoid Arthritis
In a recently accepted article published in Bioconjugate Chemistry, researchers from the University of Utah used CHPs in an antibody-conjugate to address Rheumatoid Arthritis(RA). In this paper, the authors used the Fab region from infliximab (an anti-TNFα therapy known as Remicade®) and conjugated this with CHPs. Numerous ELISA-like assays were used to verify the binding of the novel Fab-CHP was maintained, they tested the ability of Fab to bind TNFα a...

Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2

Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2
HOT OFF THE PRESS!!! A new article published in Frontiers in Immunology (impact factor: 4.72) utilized B-CHP to evaluate how the Zika virus influences renal function. The authors monitored fibrosis changes and collagen deposition in healthy and Zika infected mouse kidneys. The authors clearly link the Zika virus infection to kidney injury and elucidated the underlying molecular mechanisms for the first time. B-CHP enabled them to image the amount of da...

Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program

Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program
A new paper published in Circulation Research used CHPs as a way to study the effects of fibroblast-specific Smad3 loss on collagen fragmentation and denaturation. They found that the FS3KO (fibroblast-specific Smad3 knockout) mice showed much higher collagen degradation (Bottom) than the Smad3 fl/fl (flox/flox) mice (top). They saw that smad3 activated cardiac fibroblasts play an important protective role, preserving the ECM network, suppressing macro...

Molecular Detection and Assessment of Intervertebral Disc Degeneration via a Collagen Hybridizing Peptide

Molecular Detection and Assessment of Intervertebral Disc Degeneration via a Collagen Hybridizing Peptide
Hot off the press! Exciting new work from Dr. Xudong Li's Lab at the University of Virginia established a comprehensive and detailed quantification method of intervertebral discs in aging and inflammatory conditions. This is the first time anyone demonstrated a linear correlation between natural aging and denatured collagen content in mouse discs, and they saw a robust correlation with conventional histology techniques as well. The image below shows ho...

Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease

Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease
A newly published article in the American Journal of Physiology- Renal Physiology showed there was increased collagen remodeling in pateints with chronic kidney disease which is due to skeletal muscle fibrosis. This increase in collagen degradation was specifically visualized using F-CHP. This image shows damaged collagen (green), collagen IV (red), and cell nuclei (blue). This interesting work was performed by the Fry Lab (UTMB). Abstract: Muscle dysf...
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