Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases
In a recent publication in PLOS Biology, researchers utilized CHPs to test how DO (human leukocyte histocompatibility complex) influences the progression of autoimmune diseases. They tested CHPs in collagen-induced arthritis (CIA) mouse model involving DO knockout (KO) mice. Through this model (as well as others) they found that a lack of DO shows increased susceptibility to autoimmune diseases. CHPs (Red) showed areas with collagen degradation in the j...

Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging

Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging
We at 3Helix want to help researchers solve problems in their field and obtain new insights with our CHP products. We are working on commercializing a NEW fluorescently labeled CHP for in vivo use! The new probe will provide highly specific binding to areas of collagen turnover in animal models. This new probe has a unique sequence which interferes with their inherent ability to self-trimerize, making it easy and reliable to use in vivo. This work was ...
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