We are excited to announce a new partnership with Newcastle MRC Molecular Pathology Node and Dr. Alastair Burt who is a leading expert in liver fibrosis. This partnership will combine the histopathology expertise from Dr. Burt and the Newcastle node along with the novel CHPs developed by 3Helix to investigate liver fibrosis. The goal of this collaboration will be to first establish CHPs as a reliable stain for evaluating fibrotic progression in liver di...
An interesting article evaluating the scar formation and cardiac function in pig heart after ischemia/reperfusion (IR) injury. Researchers used CHPs in this study to evaluate the damage immediately following IR and even compared this with Masson's Trichrome staining. They found that immediately after IR, the heart does see a decrease in cardiac function in terms of ejection fraction and fractional shortening but that these conditions did not worsen afte...
Another great paper using CHPs! A recent article published in Wound Repair and Regeneration evaluated how the level of collagen denaturation within burned tissues influences the effectiveness of enzymatic debridement (removal of damaged tissue). They showed that low-temperature burns (<65 °C) had inadequate debridement, while high-temperature burns (>65 °C) had very effective debridement. By using CHPs, Sirius red (PSR), and second harmonic gener...
More exciting work using CHPs was just published in the Journal of Orthopaedic Surgery and Research! The authors examined the impact that high cholesterol had on the fibrillar architecture of the Achilles tendon in rabbits. By using B-CHPs they were able to see that rabbits with high cholesterol (hCH) had more damage to the fibrillar collagen than tissues taken from rabbits with normal cholesterol (nCH). The high-intensity regions running horizontally ...
We are excited to announce that 3Helix has rolled out a new CHP for histology! We now offer R-CHP, which has a sulfo-Cyanine 3 conjugated onto it. The R-CHP has an excitation/emission of 548/563 nm which will fluoresce in the red channel. It still has high specificity for denatured collagen and follows the same protocol as the F-CHP. Now you can image denatured collagen in the red (R-CHP) or green (F-CHP) channels on your favorite fluorescence microsco...
