Dr. Yong-Su Jin and team used CHPs in their research to follow collagen synthesis and degradation through an IPF (idiopathic pulmonary fibrosis) model using bleomycin and the resolution of fibrosis thereafter. Because biochemical assays (the golden standard) show consistently high levels of hydroxyproline content, it fails to detect that fibrosis can resolve itself. Jin et al. used CHPs and Sirius red in histopathology to observe that collagen l...
We are excited to announce a new partnership with Newcastle MRC Molecular Pathology Node and Dr. Alastair Burt who is a leading expert in liver fibrosis. This partnership will combine the histopathology expertise from Dr. Burt and the Newcastle node along with the novel CHPs developed by 3Helix to investigate liver fibrosis. The goal of this collaboration will be to first establish CHPs as a reliable stain for evaluating fibrotic progression in liver di...
Great article showcasing work our CEO and Founder, Dr. Yang Li, performed as a pilot study using human Liver tissues with biliary atresia (BA). The article describes how CHPs can be used as a novel measurement of tissue fibrosis associated with BA severity, and that CHP signal intensity can be leveraged as an early predictor to identify infants with BA with the greatest likelihood or requiring a liver transplant. The image below shows how CHP signal ca...
HOT OFF THE PRESS!!! A new article published in Frontiers in Immunology (impact factor: 4.72) utilized B-CHP to evaluate how the Zika virus influences renal function. The authors monitored fibrosis changes and collagen deposition in healthy and Zika infected mouse kidneys. The authors clearly link the Zika virus infection to kidney injury and elucidated the underlying molecular mechanisms for the first time. B-CHP enabled them to image the amount of da...
Extra! Extra! Read all about it! In a newly published paper in the American Journal of Sports Medicine, a group of PhDs and Surgeons used our F-CHPs to evaluate the collagen turnover after a complete ACL tear. They visualized the collagen turnover using CHPs (Panel D) and quantified the signal. They found that there was a statistically significant increase in dynamic collagen remodeling in the injured vastus lateralis muscle (outer quad muscle) vs the ...
A newly published article in the American Journal of Physiology- Renal Physiology showed there was increased collagen remodeling in pateints with chronic kidney disease which is due to skeletal muscle fibrosis. This increase in collagen degradation was specifically visualized using F-CHP. This image shows damaged collagen (green), collagen IV (red), and cell nuclei (blue). This interesting work was performed by the Fry Lab (UTMB).
Abstract: Muscle dysf...
