A great new article from a collaboration between Dr. Jeff Weiss's lab and our founder, Dr. Michael Yu's lab at the University of Utah. The new Acta Biomaterialia paper explores at what point collagen denaturation occurs in tendons under mechanical strain and how tendon type influences the mechanism of failure. Researchers evaluated functionally distinct tendons using positional tendons (rat tail tendons) and energy-storing tendons (rat flexor digitorum ...
Another great paper using CHPs! A recent article published in Wound Repair and Regeneration evaluated how the level of collagen denaturation within burned tissues influences the effectiveness of enzymatic debridement (removal of damaged tissue). They showed that low-temperature burns (<65 °C) had inadequate debridement, while high-temperature burns (>65 °C) had very effective debridement. By using CHPs, Sirius red (PSR), and second harmonic gener...
Extra! Extra! Read all about it! In a recent publication in the Journal of the Mechanical Behavior of Biomedical Materials, researchers from Dr. Diane Wagner's lab from Indiana evaluated the anisotropy of cartilage in an accelerated in vitro cartilage wear test. They found that CHP staining of damaged collagen highlighted that transverse (orthogonal) loading caused greater damage to collagen than with longitudinal loading. This was not due to increased ...
