We are excited to announce a research collaboration with Henkel Beauty Care Technologies (Germany), experts in skin physiology, and the developer of advanced human 3D reconstructed skin models. This interesting collaboration is investigating skin damage using their proprietary Phenion® Full-Thickness Skin Models and our CHPs. We hope to develop a useful skin testing kit together that can provide a standardized way to evaluate skin damage in vitro. Check...
Interesting new work from Dr. Jeffrey Molkentin's Lab published in The Journal of Clinical Investigation- Insight, utilized B-CHP to evaluate the effect that Hsp47 deletion has on the collagen production of myocardiocytes (top), endothelial cells (middle), and myofibroblasts (bottom) after transverse aortic constriction (TAC) surgery (a pressure overload model). Their results show that although all three cell types could produce collagen, without Hsp47...
New work from Dr. Karl Kadler's lab utilized CHPs to see how BiP influences the circadian rhythm of cells. They saw that BiP overexpression resulted in a more robust circadian rhythm but that it led to retention of procollagen in the ER as non-helical collagen and reduced the assembly of collagen fibers. They were able to visualize this by using F-CHPs. Great work and interesting findings!
Abstract: ER stress and dysregulation of collagen synthesis are...
