In a recently accepted article published in Bioconjugate Chemistry, researchers from the University of Utah used CHPs in an antibody-conjugate to address Rheumatoid Arthritis(RA). In this paper, the authors used the Fab region from infliximab (an anti-TNFα therapy known as Remicade®) and conjugated this with CHPs. Numerous ELISA-like assays were used to verify the binding of the novel Fab-CHP was maintained, they tested the ability of Fab to bind TNFα a...
Extra! Extra! Read all about it! In a recent publication in the Journal of the Mechanical Behavior of Biomedical Materials, researchers from Dr. Diane Wagner's lab from Indiana evaluated the anisotropy of cartilage in an accelerated in vitro cartilage wear test. They found that CHP staining of damaged collagen highlighted that transverse (orthogonal) loading caused greater damage to collagen than with longitudinal loading. This was not due to increased ...
It seems that CHPs are making an impact for researchers study intervertebral disc degeneration! Another interesting paper published in JCI Insight focused on intervertebral disc (and cartilage) degeneration. Researchers looked at the role of the actin-branching Arp2/3 complex has in maintaining the health of the IVD and cartilage through the regulation of cell-ECM interactions. In this study, they showed that the mutant mice (Arp2/3 deficient mice) had ...
