Scar Formation with Decreased Cardiac Function Following Ischemia/Reperfusion Injury in 1 Month Old Swine

Scar Formation with Decreased Cardiac Function Following Ischemia/Reperfusion Injury in 1 Month Old Swine
An interesting article evaluating the scar formation and cardiac function in pig heart after ischemia/reperfusion (IR) injury. Researchers used CHPs in this study to evaluate the damage immediately following IR and even compared this with Masson's Trichrome staining. They found that immediately after IR, the heart does see a decrease in cardiac function in terms of ejection fraction and fractional shortening but that these conditions did not worsen afte...

An acute immune response underlies the benefit of cardiac adult stem cell therapy

An acute immune response underlies the benefit of cardiac adult stem cell therapy
EXTRA! EXTRA! Read all about it! New research from Jeffery Molkentin's Lab recently utilized B-CHP to evaluate the mechanical and functional changes in cardiac tissue following an ischemia/reperfusion injury and evaluated the difference in the response following stem cell therapy. In Panel A, the clearly show that there is an increase in ECM remodeling at the infarct border zone compared to an area far away from the infarct. In Panel B, they show that ...
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