Localization of Therapeutic Fab-CHP Conjugates to Sites of Denatured Collagen for the Treatment of Rheumatoid Arthritis

Localization of Therapeutic Fab-CHP Conjugates to Sites of Denatured Collagen for the Treatment of Rheumatoid Arthritis
In a recently accepted article published in Bioconjugate Chemistry, researchers from the University of Utah used CHPs in an antibody-conjugate to address Rheumatoid Arthritis(RA). In this paper, the authors used the Fab region from infliximab (an anti-TNFα therapy known as Remicade®) and conjugated this with CHPs. Numerous ELISA-like assays were used to verify the binding of the novel Fab-CHP was maintained, they tested the ability of Fab to bind TNFα a...

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases
In a recent publication in PLOS Biology, researchers utilized CHPs to test how DO (human leukocyte histocompatibility complex) influences the progression of autoimmune diseases. They tested CHPs in collagen-induced arthritis (CIA) mouse model involving DO knockout (KO) mice. Through this model (as well as others) they found that a lack of DO shows increased susceptibility to autoimmune diseases. CHPs (Red) showed areas with collagen degradation in the j...
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