CHPs in nAMD

Collagen Hybridizing Peptides (CHPs) directly target damaged collagen, used to study fibrotic and inflammatory conditions. In nAMD, CHPs have been used to accurately determine disease activity and comment on reversibility of fibrotic changes. When combined, these observations can accurately delineate between patients likely to progress quickly and those whose level of disease is more likely to remain stable

nAMD Papers Utilizing CHPs

1. Collagen peptide simulated bending after applied axial deformation (Journal of Mechanical Behavior of Biomedical Materials, 2020) 

2. Use of collagen-hybridizing peptides to assess active fibrosis in 2 mouse models of choroidal neovascularization (Investigative Ophthalmology & Visual Science, 2022) 

3. Simultaneous Ang-2/VEGF-A Inhibition Prevents Subretinal Fibrosis Progression in Preclinical Mouse Models of Choroidal Neovascularization (CNV) (Investigative Ophthalmology & Visual Science, 2021)