CHPs in IPF

Collagen Hybridizing Peptides (CHPs) directly target damaged collagen, used to study fibrotic and inflammatory conditions. In IPF, CHPs can quantify damaged collagen in lung tissue, allowing for disease activity evaluation. With this ability we hope to help investigations into the underlying causes of IPF, help identify potential therapeutic targets, and evaluate the efficacy of such therapies.

IPF Papers Utilizing CHPs

1. Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis (European Respiratory Journal, 2022) 

2. Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices (Frontiers, 2021) 

3. Dopamine D1 receptor stimulates cathepsin K-dependent degradation and resorption of collagen I in lung fibroblasts (Journal of Cell Science, 2020) 

4. Preservation of Higher Levels of Denatured Collagen in Lung Tissue from Patients with Idiopathic Pulmonary Fibrosis Compared to Controls After Decellularization (University of Groningen, 2021) 

5. The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis (Journal of Molecular Medicine, 2020)