3Helix | Comprehensive Guide to Collagen Hybridizing Peptides (CHPs) – 3Helix Inc

NEWS: 3Helix and Roche publish groundbreaking research using CHPs to monitor subretinal fibrosis in vivo! | Learn More

NEWS: 3Helix named Startup of the Year at the University of Utah's Annual Innovation Awards! | Learn More

NEWS: BASF invests in 3Helix Inc! | Learn More

BLOG: Liver fibrosis Detected with CHPs in half the time it takes with Picrosirius Red | Read Here

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Collagen Science Made Simple

Collagen Hybridizing Peptides are synthetic peptides that uniquely fold into triple helices with damaged collagen molecules via the stereoelectric effect in vivo and in vitro. CHPs can be conjugated with dyes for visualization and diagnosis, and have additional applications in drug delivery and cosmetics.

Overcoming Research Challenges with CHPs

CHPs selectively bind to denatured collagen to enable accurate identification and monitoring of tissue injury and fibrosis.
CHPs enable precise detection of subtle collagen remodeling, allowing researchers to monitor early-stage fibrosis and detect initial signs of disease progression.
Due to collagen's highly conserved structure, CHPs can be used to recognize all collagen families in all animal models.
Straightforward protocols help CHPs integrate easily into existing research pipelines, reducing complexity while delivering robust results.

Expanding Applications: CHPs for Total Collagen Detection

While renowned for their ability to detect damaged collagen, CHPs also excel at quantifying total collagen content. By leveraging their unique binding properties, CHPs provide more precise and reliable results compared to traditional collagen stains Picrosirius Red (PSR) or Masson's Trichrome (MT).

Masson's Trichrome vs. Collagen Hybridizing Peptides

Unparalleled Clarity: CHPs deliver high-contrast staining, making collagen structures stand out with exceptional definition.
Replacement of Tricky Collagen Stains: CHPs can be used to evaluate total collagen and can even be counterstained for damaged collagen
Cross Species Capability, Including Human: CHPs work by recognizing collagen’s highly evolutionarily-conserved structure, and therefore work in any animal model and on any tissue that has collagen in it.

(right) CCl4 mouse livers stained using MT and CHPs [more info]

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1. Contract Terms 1.1 General Terms. These terms and conditions (“Terms”) and our quotation (if any) comprise the agreement (“Agreement”) between you and 3HELIX Inc, in which case such agreement applies, you agree to accept and be bound by the Agreement by ordering products on 3helix.com or if you receive ordering or sales documents that reference these Terms. This agreement is the complete and exclusive contract between us with repect to your purchase of the products.1.2 Term Conflict. If any conditions within the Agreement documents conflict with each other, we will give them the following priority: the quotation, and then these Terms. We expressly reject any different terms or provisions contained in any document you provide, and if the terms and conditions in this Agreement differ from the terms of your offer, this Agreement will serve as the governing terms for our contract.1.3 When Agreement Takes Effect. The Agreement between us is created when we accept your order, either by sending a written confirmation, or by shipping the product or otherwise initiating action to provide what you have ordered. 2. Definitions 2.1 3HELIX / We: 3HELIX Inc, 675 Arapeen Dr, Ste. 302, Salt Lake City, UT 84108.2.2 Customer / You: any person or organization purchasing Products from 3HELIX.2.3 Order: the Customer’s order for Products as set out on the relevant 3HELIX order form (either online or otherwise).2.4 Product: 3HELIX branded products or products distributed by 3HELIX on behalf of 3HELIX’s suppliers and available through 3HELIX’s catalog.2.5 Internal Research Purposes: in vitro or in vivo use of the Products by a party, its employees, and/or its agents as an end user in connection with its own internal research, development or educational use and expressly excludes use for Commercial Purposes.2.6 Commercial Purposes: use for any commercial purpose of any kind, including without limitation: for any therapeutic or diagnostic purpose in human; for resale or transfer in any form (including as part of a kit) to a third party; for analysis or reverse engineering of the Product; for manufacturing; for the provision of services to third parties. 3. 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In respect of Products the Customer purchases from 3HELIX or our authorized distributors, 3HELIX grants the Customer only a limited, non-exclusive, non-transferable, non-sublicensable and royalty-free right under our intellectual property: you may only use the products you have bought, and only for your Internal Research Purposes. No right to transfer, distribute or resell our products or any of their components is conveyed expressly, by implication, or by estoppel. Unless expressly permitted by 3HELIX in writing, you will not modify, change, remove, cover or otherwise obscure any of our or our affiliates’ brands, trade or service marks on the products. Nothing in the Agreement limits our ability to enforce our intellectual property rights. 10.2 Commercial Applications; Additional Rights. Unless we expressly state otherwise in writing, 3HELIX gives no rights to use Products in any non-research commercial application, including manufacturing, quality control, or non-research commercial services such as reporting the results of your non-research activities for a fee or other consideration. If the Customer wishes to use a 3HELIX Product for any non-research commercial purposes, the Customer will require an additional license from 3HELIX by contacting info@3helix.com. 10.3 Intellectual Property Ownership. We exclusively own all intellectual property rights in any inventions (patentable or otherwise), discoveries, improvements, data, know-how, or other results that are conceived, developed, discovered, reduced to practice, or generated by you alone, by or for us, or jointly by you and us, in relation to processes, methods, or related synthesis of a custom product, or otherwise in connection with designing or manufacturing a custom product. 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You must comply with the EAR and all other applicable laws, regulations, laws, treaties, and agreements relating to the export, re-export, and import of any Item. You must not, directly or indirectly, without first obtaining the required license to do so from the appropriate U.S. government agency; (a) export, re-export, distribute or supply any Item to (a) any restricted or embargoed country or to a person or entity whose privilege to participate in exports has been denied or restricted by the U.S. government; (b) any person or entity who is involved in improper development or use of nuclear weapons or of chemicals/biological weapons, or missiles, or in terrorist activities. You will, if we request, provide information on the end user and end use of any Item you export or plan to export. 11.4 Audit Cooperation. 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Any notice or communication required or permitted under these Terms must be in writing and will be deemed received when personally delivered, or 3 business days after being sent by certified mail, postage prepaid, to a party’s specified address. 12.8 Requirement to Reduce to Writing. No waiver, consent, modification, amendment or changes to the terms of this Agreement will be binding unless in writing and signed by both of us. Our failure to object to terms contained in any subsequent communication from you will not be a waiver or modification of our Agreement. Updated Jan 16, 2018

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