Mechanics and structural stability of the collagen triple helix

Mechanics and structural stability of the collagen triple helix
A great review article, written by our own Dr. Mike Kirkness, discussing the structural stability of the collagen triple helix was just published in Current Opinion in Chemical Biology. This article discusses the challenges associated with probing and understanding the mechanical properties of the collagen triple helix by modeling it as a semiflexible rod. He explains the shortcomings of current techniques and gives insight into new theories about what ...

Quantitative Liver Fibrosis Using Collagen Hybridizing Peptide to Predict Native Liver Survival in Biliary Atresia: A Pilot Study

Quantitative Liver Fibrosis Using Collagen Hybridizing Peptide to Predict Native Liver Survival in Biliary Atresia: A Pilot Study
Great article showcasing work our CEO and Founder, Dr. Yang Li, performed as a pilot study using human Liver tissues with biliary atresia (BA). The article describes how CHPs can be used as a novel measurement of tissue fibrosis associated with BA severity, and that CHP signal intensity can be leveraged as an early predictor to identify infants with BA with the greatest likelihood or requiring a liver transplant. The image below shows how CHP signal can...

Corporate Update-2

Corporate Update-2
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Acoustic modification of collagen hydrogels facilitates cellular remodeling

Acoustic modification of collagen hydrogels facilitates cellular remodeling
A newly published article from Dr. Hocking's Lab used F-CHPs to image collagen remodeling due to acoustic disturbance. They found that exposing the collagen hydrogels to ultrasound waves revealed areas of cell-mediated collagen fiber remodeling. These areas of collagen remodeling were corroborated with SHG imaging. These results indicate that ultrasound exposure does not directly alter triple-helical conformation of collagen, but sensitizes the collag...

Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2

Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2
HOT OFF THE PRESS!!! A new article published in Frontiers in Immunology (impact factor: 4.72) utilized B-CHP to evaluate how the Zika virus influences renal function. The authors monitored fibrosis changes and collagen deposition in healthy and Zika infected mouse kidneys. The authors clearly link the Zika virus infection to kidney injury and elucidated the underlying molecular mechanisms for the first time. B-CHP enabled them to image the amount of dam...

Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides

Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides
A great review article was recently published in the International Journal of Molecular Sciences that discusses how currently available collagen targeting methods are used for regenerative therapeutics. This article also compares the benefits and drawbacks of several collagen targeting strategies. (Spoiler: They highlight several key advantages CHPs have over other collagen-binding peptides). Very informative article and useful to those who are lookin...

CHP’s For Prostate Cancer Research

CHP’s For Prostate Cancer Research
For those who are interested in knowing what the future of CHP research holds, take a look at this short research highlight from the Department of Defense- Congressionally Directed Medical Research Programs. It showcases our Co-Founder Dr. Michael Yu (University of Utah) and his collaborator Dr. Martin Pomper's (John's Hopkins University) research to explore how CHPs can be used to target prostate cancer! This is just one application of CHPs that is bei...

Assessing collagen fibrils molecular damage after a single stretch–release cycle

Assessing collagen fibrils molecular damage after a single stretch–release cycle
Exciting work published in Soft Matter utilized F-CHPs to analyze molecular damage to collagen fibrils after a single asymmetrical stretch-release experiment. Researchers saw that the supramolecular fibril structure was unaffected by these experiments and that a fibril rupture is not a pre-requisite for molecular denaturation of the collagen fibril. The figure below shows how the asymmetrical stretch-release experiment was performed. The dotted line rep...

National Society For Histotechnology 2019

National Society For Histotechnology 2019
We are excited to announce that 3Helix will be attending the 2019 National Society for Histotechnology Annual Conference in New Orleans!! Tell your friends and come stop by Booth 926 to see how easy it is to use CHPs as a tissue stain! Our CTO Lucas Bennink will be giving a digital poster presentation on CHP technology on Monday, September 23rd at 4:00 pm. Bring your questions and he will gladly discuss how CHPs can help advance your research! We will b...