Another great article about intervertebral disc degeneration!!

Another great article about intervertebral disc degeneration!!
It seems that CHPs are making an impact for researchers study intervertebral disc degeneration! Another interesting paper published in JCI Insight focused on intervertebral disc (and cartilage) degeneration. Researchers looked at the role of the actin-branching Arp2/3 complex has in maintaining the health of the IVD and cartilage through the regulation of cell-ECM interactions. In this study, they showed that the mutant mice (Arp2/3 deficient mice) had ...

A multi-throughput mechanical loading system for mouse intervertebral disc

A multi-throughput mechanical loading system for mouse intervertebral disc
A new article published in the Journal of the Mechanical Behavior of Biomedical Materials used F-CHPs (Figure 7) to assess the damage in an intervertebral disc (IVD) model. Researchers used CHPs to help validate their new mouse disc organ culture system by dynamically applying compression loading in a customized micro-culture device tailored for mouse lumbar discs. They tested native, static, and loaded discs to see how mechanical damage affects disc he...

Malaria parasite immune evasion and adaptation to its mosquito host is influenced by the acquisition of multiple blood meals

Malaria parasite immune evasion and adaptation to its mosquito host is influenced by the acquisition of multiple blood meals
Another great article using CHPs! In this interesting paper, coming out of Dr. Ryan C. Smith's lab from Iowa State, they utilized CHPs to examine the damage done in the midgut of mosquitoes after blood or protein meal feeding. They go on to say that this damage from multiple feedings impacts malaria oocytes' survival. They found that human malaria parasites captured host resources to facilitate their growth after multiple feedings when the basal lamina ...

Tendon tissue microdamage and the limits of intrinsic repair

Tendon tissue microdamage and the limits of intrinsic repair
Interesting work done in Jess Snedeker's lab was recently published in Matrix Biology. This work evaluated how microdamage to rat tail tendon fascicles influenced the ability of tenocytes (tendon fibroblasts) to aid in repair. This was probed by stretching fascicles up to 8% strain, using CHPs to stain for collagen damage, and then looking at the functional recovery of the fascicles up to 7 days after initial strain. They also looked at cell viability u...

Raman Spectroscopy: Guiding Light for the Extracellular Matrix

Raman Spectroscopy: Guiding Light for the Extracellular Matrix
 A very interesting review article recently published in Frontiers in Bioengineering and Biotechnology explores how Raman Spectroscopy (RS) can be used to investigate the ECM. They showcase how RS can be helpful in probing the subtle structural changes in the ECM in cartilage, bone, cancer, and collagen assessment. They can distinguish between collagen and other ECM proteins due to the unique triple-helix and the amino acid composition. However, the dis...

Uterine perfusion model for analyzing barriers to transport in fibroids

Uterine perfusion model for analyzing barriers to transport in fibroids
Interesting work from Dr. You Han Bae's lab at the University of Utah used F-CHPs aid in evaluating tissue perfusion and identifying barriers to transport in uterine fibroids. Fibroids are growths of dense connective tissue that lack vasculature for the transport of drugs to the area. They show that there is a negative relationship between collagen density and methylene blue distribution (used as a model molecule for tissue perfusion). They noted limit...

The Impact of Skeletal Muscle Contraction on CD146+Lin- Pericytes

The Impact of Skeletal Muscle Contraction on CD146+Lin- Pericytes
Interesting new work published in The American Journal of Physiology- Cell Physiology evaluated the ability of muscle-derived pericyte to contribute to skeletal muscle remodeling in response to training. The researchers used electric stimulation to contract muscles and monitor the response of pericyte cells. They found that the CD146+ Lin- pericyte cells were the most sensitive to contraction and they contribute to upregulating ECM remodeling and angio...

Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis

Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis
A recent article published in the International Journal of Molecular Sciences utilized CHPs to verify the health of collagen in their MSC-ECM complexes. The authors developed a clumped-MSC/ECM (C-MSC) complex under serum-free conditions that allows bone regeneration upon implantation without the use of an artificial scaffold. They grew the C-MSC and compared a cellularized vs decellularized C-MSCs for their ability to promote osteogenesis after implanta...

Mechanics and structural stability of the collagen triple helix

Mechanics and structural stability of the collagen triple helix
A great review article, written by our own Dr. Mike Kirkness, discussing the structural stability of the collagen triple helix was just published in Current Opinion in Chemical Biology. This article discusses the challenges associated with probing and understanding the mechanical properties of the collagen triple helix by modeling it as a semiflexible rod. He explains the shortcomings of current techniques and gives insight into new theories about what...

Quantitative Liver Fibrosis Using Collagen Hybridizing Peptide to Predict Native Liver Survival in Biliary Atresia: A Pilot Study

Quantitative Liver Fibrosis Using Collagen Hybridizing Peptide to Predict Native Liver Survival in Biliary Atresia: A Pilot Study
Great article showcasing work our CEO and Founder, Dr. Yang Li, performed as a pilot study using human Liver tissues with biliary atresia (BA). The article describes how CHPs can be used as a novel measurement of tissue fibrosis associated with BA severity, and that CHP signal intensity can be leveraged as an early predictor to identify infants with BA with the greatest likelihood or requiring a liver transplant. The image below shows how CHP signal ca...
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