A great review article was recently published in the International Journal of Molecular Sciences that discusses how currently available collagen targeting methods are used for regenerative therapeutics. This article also compares the benefits and drawbacks of several collagen targeting strategies. (Spoiler: They highlight several key advantages CHPs have over other collagen-binding peptides). Very informative article and useful to those who are looking to target the ECM in tissue disease and repair.

Abstract: Collagen is the most widespread extracellular matrix (ECM) protein in the body and is important in maintaining the functionality of organs and tissues. Studies have explored interventions using collagen-targeting tissue engineered techniques, using collagen hybridizing or collagen binding peptides, to target or treat dysregulated or injured collagen in developmental defects, injuries, and diseases. Researchers have used collagen-targeting peptides to deliver growth factors, drugs, and genetic materials, to develop bioactive surfaces, and to detect the distribution and status of collagen. All of these approaches have been used for various regenerative medicine applications, including neovascularization, wound healing, and tissue regeneration. In this review, we describe in depth the collagen-targeting approaches for regenerative therapeutics and compare the benefits of using the different molecules for various present and future applications.


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